Advancing cardiovascular science.

Clinical research is how today's unanswered questions become tomorrow's standard of care.

Advanced Heart Failure

Support is not always permanent. Some hearts come back, and the work asks which ones, and why.

Three-quarter anterior view of a real heart, rendered from the BodyParts3D anatomical model: the great vessels arch over the top, and the coronary arteries and veins trace the surface

Move the lens to look inside the heartDrag the lens to look inside the heart

Heart render from BodyParts3D, © Database Center for Life Science, CC BY-SA 2.1 JP

100+

Peer-reviewed articles and abstracts, and the questions that keep coming.

Every one of them starts as a question from clinic, and the record keeps growing because the questions do.

Google Scholar

The clinical trial program.

Investigator-initiated research and multicenter trials, bringing tomorrow's therapies to patients close to home. A selection of active and recent studies.

Dr. Yaranov reading the imaging monitors in the catheterisation lab

In the cath lab · where the trial questions come from

Heart illustrations by Patrick J. Lynch, medical illustrator, and C. Carl Jaffe, MD, cardiologist (CC BY 2.5); LVAD illustration by Blausen.com staff (CC BY 3.0). Cut out and colour graded.

Cardiac amyloidosis

  • TRITON-CMSite PINucresiran in ATTR cardiomyopathy (Alnylam).
  • DEPLETTR-CMPIAmyloid depleter in ATTR cardiomyopathy.
  • MAESTTROPIReal-world ATTR amyloidosis outcomes.

Mechanical support and devices

  • INNOVATESite PIMagnetically levitated VAD for refractory heart failure.
  • TEAM-HF IDESite PIMechanical support in advancing heart failure.
  • RELIEVE-HFSub-IInteratrial shunt for advanced heart failure.

Heart failure pharmacology

  • GALACTIC-HFSub-IOmecamtiv mecarbil in reduced ejection fraction.
  • VICTORIASub-IVericiguat in worsening heart failure.
  • PIONEER-HFSub-ISacubitril and valsartan after decompensation.

Heart illustrations by Patrick J. Lynch, medical illustrator, and C. Carl Jaffe, MD, cardiologist (CC BY 2.5); LVAD illustration by Blausen.com staff (CC BY 3.0). Cut out and colour graded.

Selected publications.

2020

2022

2025

All 100 plus on Google Scholar

Every paper starts as a question I could not answer at the bedside.

  1. Which failing hearts recover on mechanical support

    Support is not always permanent. Some hearts come back, and the work asks which ones, and why.

  2. Who the transplant list keeps waiting, and why

    Allocation is a policy question as much as a clinical one. The papers look at who waits, and what could change it.

  3. Finding cardiac amyloidosis before it is late

    A disease mistaken for normal aging. The research is about catching it while treatment still changes the outcome.

  4. Getting proven therapy to patients earlier

    The therapy already exists. The gap is reaching patients in time, and that gap is worth studying.

Overhead view of Dr. Yaranov's hand on a laptop trackpad at his desk, his other hand resting at his chin

Areas of research interest.

  • 05Cardiometabolic Disease
  • 06Cardiac Longevity
  • 08Medical Devices
  • 09Pharmacological Clinical Trials
  • 10Healthcare Innovation
  • 11Outcomes Research

Discuss a research collaboration.

Open to pharmaceutical, biotechnology, and medical device companies, CROs, academic investigators, and healthcare innovators.

Discuss a collaboration The record on Google Scholar

A regional multidisciplinary research network serving , , and .